by J C

Questions for the Lion Tamer

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Headscratcher from “Tryptamine Palace”

While much of the discussion surrounding DMT revolves around N,N-dimethyltryptamine, it’s close relative 5-methoxy-N,N-dimethyltryptamine (5-MEO-DMT) seems to be gaining interest in recent times. James Oroc would author a book titled “Tryptamine Palace: 5-MeO-DMT and the Sonoran Desert Toad”. In this book, Oroc would summarize his experiences with 5-MEO-DMT and his speculations as to what role it plays within the natural world. It’s a compelling book and gives insight into the lesser known of the DMT’s.

While DMT experiencers across the world have been describing their interaction with the molecule for many years now, it is a rarity to hear a story that truly boggles the mind. Obviously stories are stories and cannot supplant “scientific evidence” but sometimes they can operate as a catalyst to previously suppressed insights. This story by James Oroc does just that.

(Beginning on page

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Mechanics of “Miracles from Heaven”


Q4LT is hardly embracing a religious perspective in this piece. The title “Miracles from Heaven” has to do with the movie about a young girl named Annabel Beam. In 2011, ten year old Annabel suffered from conditions known as pseudo-obstruction motility disorder (POMD) and antral hypomotility disorder (AHD). POMD is caused by the severe impairment of the intestines to push food through the digestive tract (peristalsis). It’s been stated that this condition may be caused by an injury to the smooth muscle or the nervous system of the gastrointestinal tract. AHD is characterized by weak contractions in the antrum, the funnel shaped lowermost part of the stomach. As of 2016, it appears as though both of these conditions in combination are extremely difficult to address with many secondary illnesses arising from them. Annabel’s case was considered a chronic situation that would

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Wim Hof Method Workshop Review (San Francisco)

On Sunday, October 23, 2016 Wim Hof and his team produced a workshop at Treasure Island in the San Francisco Bay Area. It comprised of a gathering of over 200 people who were made up of a combination of WHM practitioners and a few curious souls. In speaking with event organizer Laura Hof (Wim’s daughter), it seems as though upwards of 500 requests were made to attend the gathering but due to limited venue capacity an accommodation was made for slightly over 200.

The workshop would start at 2:30 p.m. with Isabelle Hof (also Wim’s daughter) taking the stage, playing a short video intro to the WHM, and laying out the timeline for the workshop. She would then introduce Wim who would engage the audience with the story of his journey, experiences in climbing sub-zero mountains, and training people up to 76 years of age to do so. He would also discuss the scientific studies surrounding WHM and

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Future DMT Studies

There are many perspectives on “The Spirit Molecule” and what it’s natural role in the human body signifies. There are dozens of theories regarding this but as of this moment, without the implementation of scientific scrutiny, it’s difficult to quantify much of them.

I have listed a few studies that I would like to see take place in the future regarding both endogenous DMT measurement and exogenous DMT administration.

1. Measuring DMT Formation in Humans (Endogenous Study)
This study is based on the piece written here at Q4LT that provides an in-depth perspective on systemic changes to human physiology that take place during moments appeared to be linked to endogenous DMT synthesis (dreaming, Wim Hof Method, meditation, hypnosis, out of body experiences, hypnagogia, sleep paralysis, energetic “healers”, fasting, dark room retreats/sensory deprivation). It’s a pretty self explanatory

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Placebo Effect

“That’s just a placebo effect.”

“It could be placebo.”

“Have you ever heard of the placebo effect?”

The standardized definition of the “Placebo Effect” is as follows… a beneficial effect, produced by a placebo drug or treatment, that cannot be attributed to the properties of the placebo itself, and must therefore be due to the patient’s belief in that treatment.

The scientific establishment has accepted the placebo effect to be a true phenomena observed in thousands of scientific studies across the world. In fact, all drug development is compared versus placebo in order to verify whether the drug provides greater efficacy than the “power of belief”. The mechanisms for which this phenomena transpires has seemingly yet to be fully deciphered. The concept of “belief” having a direct effect on physiology has seemingly perplexed the scientific community. However, since “belief” would

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5HT2A Receptor Test… Tricky Business

Serotonin is a neurotransmitter derived from tryptophan and is primarily found in the central nervous system, blood platelets, and the gastrointestinal tract. A receptor is a protein molecule that receives chemical signals (ex: Serotonin) from outside a cell. When these chemical signals bind to a receptor, they cause some form of cellular/tissue response. Each receptor is linked to a specific cellular biochemical pathway. While numerous receptors are found in most cells, each receptor will only bind with molecules of a particular structure (ex: lock and key). Throughout the body, serotonin receptors are abbreviated as 5-HT (5-hydroxytryptamine) receptors. These 5-HT receptors are responsible for modulating the release of numerous neurotransmitters (ex: GABA, dopamine) and hormones (ex: oxycotin, cortisol). In general, serotonin is thought of as contributing to feelings of well-being.

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Cannabis-DMT Relationship

Tetrahydrocannabinol (THC) is considered to be the primary psychoactive constituent of cannabis. While THC provides a distinct set of subjective as well as physiological effects throughout the body, they are described as being distinctly different than a high-dose DMT experience from exogenous means. Those that have indulged in ingesting DMT or Ayahuasca might claim that there is no comparison between the effects of cannabis and the vaunted “Spirit Molecule”.

Cannabis use has gradually increased in America due to it’s legalization in a few states as well as the implementation of “medical marijuana” laws. With increasingly efficient and optimized cultivation techniques in place, the potency of the plant and secondary products have expanded exponentially. It would seem logical that people begin to report a vast array of different subjective experiences from the plant. Some people have

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Futuristic Medicine

As a young child, there were a few kids among the masses that exuded the coordination to ride a bicycle without the need for training wheels. “Training wheels” are an additional set of smaller wheels that attach to the rear wheels of a bicycle in order to provide additional stability. This then allows a young child the ability to ride their bikes without fear of falling over. As time progresses and the child develops greater coordination and balance, the training wheels are then removed.

A recent 2016 study published in the journal Scientific Reports observed that 8 chronic spinal cord injury (SCI) paraplegics would experience neurological improvements in addition to regaining voluntary motor control in muscles below the (SCI) level leading to marked improvement in their walking index. This study would take place over 12 months and utilize brain-machine interfaces (BMIs) including

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Random Facts & Speculations

Some people like to make the claim… “DMT is everywhere!”.

While this not might be technically 100% true, the ubiquitousness with which it occurs cannot be denied. Hundreds of plants and every mammal tested thus far have showcased varying levels of “The Spirit Molecule” residing within them. Being that dimethyltryptamine (DMT) is still classified as a Schedule I substance alongside heroin and methamphetamines makes it all the more perplexing.

When the general public hears the word “Ayahuasca”, it generally tends to carry with it connotations of exotic plants found within the Amazonian jungle. This shamanic brew is comprised of plants found within this region that contain DMT and monoamine oxidase inhibitors (MAOIs).

In 2013, the Journal of Agricultural & Food Chemistry published a study regarding the occurrence and distribution of tryptamines in citrus plants. There were 6 different

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Measuring DMT Formation in Humans

(Here is a printer friendly version of this article in PDF format.)

It’s not an all or nothing aspect of life.

Ingesting one “shot” of alcohol has significantly different physical effects on a person compared to ingesting 8 “shots”. The same goes for ingesting a cannabis edible equivalent of 10mg THC versus an 80mg THC dose. This thought process can extend to virtually anything in life… consuming one chicken drumstick vs. eight drumsticks, sleeping one hour vs. eight hours, spending one hour in the sun vs. eight hours, etc. It would seem rather silly to focus solely on the effects of only high-end doses while discarding the varying effects that take place between the low and top end.

In Dr. Rick Strassman’s study outlined in his book “DMT: The Spirit Molecule” there were four different doses (0.05mg/kg, 0.1mg/kg, 0.2mg/kg, and 0.4mg/kg) administered to the majority of volunteers. This

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